Cross reactivity of cephalosporin antibiotics in patients with penicillin allergy is 5% for first generation drugs, and 1% for third generation drugs, so these drugs should be used unless there is a history of anaphylaxis with penicillin administration. If there is a concern, patients should be referred for allergy testing prior to administering antibiotic prophylaxis.
- Terico AT, Gallagher JC "Beta-lactam Hypersensitivity and Cross-Reactivity" J Pharm Pract 2014 Dec;27(6):530-44
- Olmos, C., et al. (2014). "Prognostic implications of diabetes in patients with left-sided endocarditis: findings from a large cohort study." Medicine (Baltimore) 93(2): 114-119.
- Chrastil, J., et al. (2015). "Is Hemoglobin A1c or Perioperative Hyperglycemia Predictive of Periprosthetic Joint Infection or Death Following Primary Total Joint Arthroplasty?" J Arthroplasty 30(7): 1197-1202.
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